7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

Base Information

Chemical Name:7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one
CAS No.:1607803-67-7
Molecular Formula:C₁₆H₁₇NO₅
Molecular Weight:303.315
Hs Code.:

Synonyms:7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

Suppliers and Price of 7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BI09
5mg
$ 440.00

Tocris
BI09 ≥98%(HPLC)
10
$ 227.00

Tocris
BI09 ≥98%(HPLC)
50
$ 951.00

ChemScene
BI09 99.60%
100mg
$ 1300.00

ChemScene
BI09 99.60%
50mg
$ 750.00

ChemScene
BI09 99.60%
10mg
$ 200.00

ChemScene
BI09 99.60%
5mg
$ 130.00

Total 3 raw suppliers

Chemical Property of 7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

BI09 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses B I09, is a novel chromenone-based covalent inhibitors of IIRE-1 RNase. It Inhibits IRE-1/XBP1 pathway, and thus growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

Technology Process of 7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

There total 4 articles about 7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1607803-65-5
allyl-7-(1,3-dioxan-2-yl)-8-hydroxy-5-oxo-4,5-dihydro-1H-chromeno[3,4-c]pyridine-3(2H)-carboxylate

: 1607803-67-7
7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 0.416667h; Inert atmosphere;
DOI:10.1021/jm5002452

Reference yield:

: 1607803-61-1
allyl-(2-(7-hydroxy-2-oxo-2H-chromen-4-yl)ethyl)carbamate

: 1607803-67-7
7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride; pyridine / acetonitrile / 6 h / 20 °C / Inert atmosphere

1.2: 18 h / 95 °C / Inert atmosphere

1.3: 2 h / 60 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / benzene / 2 h / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 0.42 h / 20 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic anhydride; toluene-4-sulfonic acid; In dichloromethane; acetonitrile; benzene; 1.1: |Duff Aldehyde Synthesis;
DOI:10.1021/jm5002452

Reference yield:

: 1607803-37-1
allyl-7-formyl-8-hydroxy-5-oxo-4,5-dihydro-1H-chromeno[3,4-c]pyridine-3(2H)-carboxylate

: 1607803-67-7
7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / benzene / 2 h / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 0.42 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; In dichloromethane; benzene;
DOI:10.1021/jm5002452