3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde

Base Information

Chemical Name:3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde
CAS No.:1607803-46-2
Molecular Formula:C₂₀H₁₇NO₄
Molecular Weight:335.359
Hs Code.:

Synonyms:3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde

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Chemical Property of 3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde

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Technology Process of 3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde

There total 7 articles about 3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1607803-67-7
7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

: 100-39-0
benzyl bromide

: 1607803-46-2
3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1607803-37-1
allyl-7-formyl-8-hydroxy-5-oxo-4,5-dihydro-1H-chromeno[3,4-c]pyridine-3(2H)-carboxylate

: 1607803-46-2
3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / benzene / 2 h / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 0.42 h / 20 °C / Inert atmosphere

3: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

4: water / 1 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm5002452

Reference yield:

: 1607803-65-5
allyl-7-(1,3-dioxan-2-yl)-8-hydroxy-5-oxo-4,5-dihydro-1H-chromeno[3,4-c]pyridine-3(2H)-carboxylate

: 1607803-46-2
3-benzyl-8-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-chromeno[3,4-c]pyridine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 0.42 h / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3: water / 1 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm5002452