Technology Process of (S)-4-benzyl-9-hydroxy-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid
There total 9 articles about (S)-4-benzyl-9-hydroxy-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: aminosulfonic acid; sodium chlorite; sulfuric acid / acetonitrile; water / 0.17 h / 20 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 20 °C
2.2: 1.05 h / 0 °C
3.1: xylene / 0.5 h / 120 °C
4.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.55 h / 20 °C
5.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C
6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran
With
sodium chlorite; sulfuric acid; aminosulfonic acid; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; xylene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 20 °C
1.2: 1.05 h / 0 °C
2.1: xylene / 0.5 h / 120 °C
3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.55 h / 20 °C
4.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C
5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran
With
water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; xylene;
![(S)-4-benzyl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid](/Databaselist/images/loading.webp)
