(3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate

Base Information

Chemical Name:(3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate
CAS No.:1445984-80-4
Molecular Formula:C₃₀H₂₉Cl₂N₃O₃
Molecular Weight:550.485
Hs Code.:

Synonyms:(3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate

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Chemical Property of (3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate

Chemical Property:

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Technology Process of (3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate

There total 11 articles about (3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445984-79-1
(3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pirrolidin-3-yl benzoate

: 85482-13-9
2,5-dichlorobenzylbromide

: 1445984-80-4
(3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 1224640-13-4
1-cyclopropyl-1,2,3,4-tetrahydro-quinoxaline

: 1445984-80-4
(3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / water; 1,2-dichloro-ethane / 20 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 - 20 °C

4: piperidine / N,N-dimethyl-formamide / 20 °C

5: potassium carbonate / acetonitrile / 2 h / 20 °C

With piperidine; hydrogenchloride; di-isopropyl azodicarboxylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445984-78-0
(2S,4S)-(9H-fluoren-9-yl)methyl 4-(benzoyloxy)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pirrolidine-1-carboxylate

: 1445984-80-4
(3S,5S)-5-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-1-(2,5-dichlorobenzyl)pirrolidin-3-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / N,N-dimethyl-formamide / 20 °C

2: potassium carbonate / acetonitrile / 2 h / 20 °C

With piperidine; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308