6-[(2,2-Diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide

Base Information

Chemical Name:6-[(2,2-Diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide
CAS No.:313345-11-8
Molecular Formula:C₂₇H₃₁N₇O
Molecular Weight:469.589
Hs Code.:
DSSTox Substance ID:DTXSID50436274

Synonyms:313345-11-8;6-[(2,2-Diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide;6-((2,2-Diphenylethyl)amino)-N-(2-(piperidin-1-yl)ethyl)-9H-purine-2-carboxamide;6-[(2,2-diphenylethyl)amino]-N-[2-(piperidin-1-yl)ethyl]-9H-purine-2-carboxamide;SCHEMBL5723452;DTXSID50436274;BPIMMPFCJPUPKK-UHFFFAOYSA-N

Suppliers and Price of 6-[(2,2-Diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[(2,2-Diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:469.25900864
Heavy Atom Count:35
Complexity:627

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(CC1)CCNC(=O)C2=NC3=C(C(=N2)NCC(C4=CC=CC=C4)C5=CC=CC=C5)NC=N3

Technology Process of 6-[(2,2-Diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide

There total 6 articles about 6-[(2,2-Diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-[(2,2-Diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carboxamide

: 313345-11-8
6-[(2,2-diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide

Guidance literature:: With hydrogenchloride; In ethanol;

Reference yield:

: 27578-60-5
1-(2-aminoethyl)piperidine

: 313345-13-0
6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylic acid

: 313345-11-8
6-[(2,2-diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide

Guidance literature:: 6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 5h;

1-(2-aminoethyl)piperidine; at 20 ℃; for 20h; Product distribution / selectivity;

Reference yield:

: 27578-60-5
1-(2-aminoethyl)piperidine

: 313345-11-8
6-[(2,2-diphenylethyl)amino]-N-[2-(1-piperidinyl)ethyl]-9H-purine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.5 h / 20 °C / Large scale

2: trifluoroacetic acid / water; isopropyl alcohol / 2 h / pH 9.8 - 10 / Reflux; Large scale

With trifluoroacetic acid; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/op700248t