Technology Process of 5-methyl-9,9-dimethoxy-12-(carbophenoxy)-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooctindole
There total 12 articles about 5-methyl-9,9-dimethoxy-12-(carbophenoxy)-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooctindole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfuric acid;
In
methanol;
for 16h;
Ambient temperature;
DOI:10.1021/jo00345a004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 71 percent / LiI / acetone / 1.) 0 deg C, 2.) 25 deg C, 3.5 h
2: 98 percent / K2CO3 / methanol; H2O / 2 h / Ambient temperature
3: 94 percent / poly(vinylpyridinium chlorochromate) (PVPCC) / CH2Cl2 / 168 h / Ambient temperature
4: 82 percent / dimethylformamide / 0.75 h / 100 °C
5: 92 percent / 1.) dimethyl sulfoxide, oxalyl chloride, 2.) triethylamine / CH2Cl2 / 1.) -78 deg C, 30 min, 2.) from -78 deg C to room temperature
6: 50 percent / concd H2SO4 / methanol / 16 h / Ambient temperature
With
oxalyl dichloride; poly(vinylpyridinium chlorochromate); sulfuric acid; potassium carbonate; dimethyl sulfoxide; triethylamine; lithium iodide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00345a004
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / poly(vinylpyridinium chlorochromate) (PVPCC) / CH2Cl2 / 168 h / Ambient temperature
2: 82 percent / dimethylformamide / 0.75 h / 100 °C
3: 92 percent / 1.) dimethyl sulfoxide, oxalyl chloride, 2.) triethylamine / CH2Cl2 / 1.) -78 deg C, 30 min, 2.) from -78 deg C to room temperature
4: 50 percent / concd H2SO4 / methanol / 16 h / Ambient temperature
With
oxalyl dichloride; poly(vinylpyridinium chlorochromate); sulfuric acid; dimethyl sulfoxide; triethylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00345a004
