1-chloro-3-(hex-1-yn-1-yl)benzene

Base Information

• Chemical Name: 1-chloro-3-(hex-1-yn-1-yl)benzene
• CAS No.: 1046817-98-4
• Molecular Formula: C₁₂H₁₃Cl
• Molecular Weight: 192.688
• Mol file: 1046817-98-4.mol

Synonyms:1-chloro-3-(hex-1-yn-1-yl)benzene

Chemical Property of 1-chloro-3-(hex-1-yn-1-yl)benzene

Chemical Property:

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Technology Process of 1-chloro-3-(hex-1-yn-1-yl)benzene

There total 1 articles about 1-chloro-3-(hex-1-yn-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-iodochlorobenzene (625-99-0) + hex-1-yne (693-02-7) → 1-chloro-3-(hex-1-yn-1-yl)benzene (1046817-98-4)

Guidance literature:

With copper(l) iodide; cobalt; potassium carbonate; triphenylphosphine; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-2008-1072615

Reference yield: 82.0%

1-chloro-3-(hex-1-yn-1-yl)benzene (1046817-98-4) + bis(pinacol)diborane (73183-34-3) → (Z)-2-(1-(3-chlorophenyl)-1-hexen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:

With chloro[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene]copper(I); sodium hydroxide; In methanol; at 20 ℃; for 12h; Sealed tube;

Reference yield: 82.0%

2-phenylisatogen (1969-74-0) + 1-chloro-3-(hex-1-yn-1-yl)benzene (1046817-98-4) → 3-butyl-2-(3-chlorophenyl)spiro[indene-1,2’-indolin]-3’-one

Guidance literature:

With silver hexafluoroantimonate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 28h; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1039/c9cc05719f

upstream raw materials:

3-iodochlorobenzene

hex-1-yne