ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Base Information

Chemical Name:ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate
CAS No.:167556-65-2
Molecular Formula:C₁₈H₁₂BrF₂NO₃
Molecular Weight:408.199
Hs Code.:

Synonyms:ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Suppliers and Price of ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Chemical Property:

Purity/Quality:: 99.0%min. ^*data from raw suppliers

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Technology Process of ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

There total 7 articles about ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-2-(4-Bromo-2,5-difluoro-benzoyl)-3-(4-fluoro-phenylamino)-acrylic acid ethyl ester

: 167556-65-2
ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 1h; Yield given; Heating;
DOI:10.1021/jm00014a005

Reference yield:

: 399-94-0
2-bromo-1,4-difluorobenzene

: 167556-65-2
ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / AlCl₃ / 1.5 h / 95 °C

2: 58 percent / NaH / 3 h / Ambient temperature

3: tetrahydrofuran / Ambient temperature

4: dioxane / 60 h / Heating

5: K₂CO₃ / dimethylformamide / 1 h / Heating

With aluminium trichloride; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00014a005

Reference yield:

: 28314-82-1
4-bromo-2,5-difluorobenzoic acid

: 167556-65-2
ethyl 7-bromo-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / Heating

2: 73 percent / BuLi

3: tetrahydrofuran / Ambient temperature

4: dioxane / 60 h / Heating

5: K₂CO₃ / dimethylformamide / 1 h / Heating

With n-butyllithium; thionyl chloride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00014a005