8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester
• CAS No.: 1026473-56-2
• Molecular Formula: C₃₁H₂₆N₂O₆
• Molecular Weight: 522.557
• Mol file: 1026473-56-2.mol

Synonyms:8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester

Chemical Property of 8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester

There total 7 articles about 8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

8-amino-2-methoxycarbonyl-4-oxo-4H-1-benzopyran (195433-47-7) + 1-methyl-4-oxo-2-(3-phenylpropyl)-1,4-dihydroquinoline-6-carboxylic acid → 8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester (1026473-56-2)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 24h;

DOI:10.1016/S0223-5234(97)83282-5

Reference yield:

1-Bromo-3-phenylpropane (637-59-2) → 8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester (1026473-56-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) Mg / 1.) THF, reflux, 2 h, 2.) THF, room temperature, 1 h

2: 57 percent / diphenyl ether / 1.) 140 deg C, 45 min, 2.) reflux, 2 h

3: 93 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 50 deg C, 3 h

4: 90 percent / LiOH*H₂O / H₂O; methanol; tetrahydrofuran / 0.5 h / Heating

5: 22 percent / DMAP, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 24 h

With dmap; lithium hydroxide; sodium hydride; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; diphenylether; dichloromethane; water;

DOI:10.1016/S0223-5234(97)83282-5

Reference yield:

N-(3-acetyl-2-hydroxyphenyl)acetamide (103205-33-0) → 8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester (1026473-56-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaOEt, 2.) HCl / 1.) THF, EtOH, reflux, 3 h, 2.) THF, EtOH, reflux, 1.5 h

2: 90 percent / HCl / 22 h / Heating

3: 22 percent / DMAP, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 24 h

With hydrogenchloride; dmap; sodium ethanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/S0223-5234(97)83282-5

upstream raw materials:

8-amino-2-methoxycarbonyl-4-oxo-4H-1-benzopyran

1-Bromo-3-phenylpropane

N-(3-acetyl-2-hydroxyphenyl)acetamide

2,2-Dimethyl-5-(1-methylsulfanyl-4-phenyl-butylidene)-[1,3]dioxane-4,6-dione