103205-33-0

Basic information

• Product Name: 3'-Acetylamino-2'-hydroxyacetophenone
• Synonyms: 3'-Acetylamino-2'-hydroxyacetophenone;N-(3-Acetyl-2-hydroxyphenyl)acetaMide;Acetamide, N-(3-acetyl-2-hydroxyphenyl)-
• CAS NO: 103205-33-0
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.19924
• Mol File: 103205-33-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 130-131℃
• Boiling Point: 377.5±32.0 °C(Predicted)
• Appearance: /
• Density: 1.267
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.46±0.40(Predicted)
• CAS DataBase Reference: 3'-Acetylamino-2'-hydroxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Acetylamino-2'-hydroxyacetophenone(103205-33-0)
• EPA Substance Registry System: 3'-Acetylamino-2'-hydroxyacetophenone(103205-33-0)

Safety Data

• Hazardous Substances Data: 103205-33-0(Hazardous Substances Data)

Usage

Uses

3-Acetamido-2-hydroxyacetophenone is used in the preparation fo Antitumor Agents in Breast Cancer.

Upstream product

• 93-26-5 2-methoxyacetanilide 
• 614-80-2 2-(acetylamino)phenol 
• 95-55-6 2-amino-phenol 

Downstream Products

• 179911-56-9 N-[2-(4-Dimethylamino-phenyl)-4-oxo-4H-chromen-8-yl]-acetamide 
• 1026473-56-2 8-{[1-Methyl-4-oxo-2-(3-phenyl-propyl)-1,4-dihydro-quinoline-6-carbonyl]-amino}-4-oxo-4H-chromene-2-carboxylic acid methyl ester 
• 179911-55-8 N-{3-[(E)-3-(4-Dimethylamino-phenyl)-acryloyl]-2-hydroxy-phenyl}-acetamide 
• 132592-98-4 acetic acid-[2-hydroxy-3-(2-methoxy-trans-cinnamoyl)-anilide] 
• 132592-99-5 acetic acid-[2-hydroxy-3-(4-methoxy-trans-cinnamoyl)-anilide] 
• 113063-32-4 3'-acetylamino-2'-hydroxy-3,4-methylenedioxy-trans-chalcone 

Relevant articles and documents

Method for preparing N-(3-acetyl-2-hydroxyphenyl)acetamide

The invention relates to the technical field of organic synthesis and medicine, and provides a method for preparing N-(3-acetyl-2-hydroxyphenyl)acetamide. According to the method, 2-aminophenol is adopted as an initial raw material, amidogen acetylation and a methylation reaction of phenolic hydroxyl groups are firstly carried out, then bromination on benzene rings is carried out, acetyl is introduced, reductive debromination is finally carried out, a target product is obtained, and the total yield reaches up to 41.7%. In the process of generating a compound E through a compound D, the compound D is subjected to ether bond cracking, and can react with acetylchloride to generate phenolic ester, and then a rearrangement reaction occurs. According to the method, the raw material is wide in source and easy to obtain, the path can be industrialized easily, fewer impurities are generated, the yield is high, and the purity of the target product is effectively improved.