(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

Base Information

Chemical Name:(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole
CAS No.:366789-55-1
Molecular Formula:C₃₇H₄₀N₂O₆Si
Molecular Weight:636.82
Hs Code.:

Synonyms:(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

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Chemical Property of (3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

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Technology Process of (3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

There total 5 articles about (3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 366789-54-0
(3R/S)-6-benzyloxy-3-(tert-butyldiphenylsilyl)oxymethyl-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

: 366789-55-1
(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 16h; under 2250.18 Torr;
DOI:10.1016/S0968-0896(01)00098-0

Reference yield:

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 366789-55-1
(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / EDC / dimethylformamide / 20 h / 50 °C

2: 92 percent / Et₃N; DMAP / CH₂Cl₂ / 16 h / 60 °C

3: 64 percent / H₂ / 10 percent Pd/C / ethyl acetate / 16 h / 20 °C / 2250.18 Torr

With dmap; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00098-0

Reference yield:

: 366789-52-8
6-benzyloxy-3-hydroxymethyl-2,3-dihydro-1H-indole

: 366789-55-1
(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / EDC / dimethylformamide / 20 h / 50 °C

2: 92 percent / Et₃N; DMAP / CH₂Cl₂ / 16 h / 60 °C

3: 64 percent / H₂ / 10 percent Pd/C / ethyl acetate / 16 h / 20 °C / 2250.18 Torr

With dmap; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00098-0