1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine

Base Information

• Chemical Name: 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine
• CAS No.: 116835-06-4
• Molecular Formula: C₁₃H₈N₆O₆
• Molecular Weight: 344.243
• Mol file: 116835-06-4.mol

Synonyms:1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine

Chemical Property of 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine

There total 10 articles about 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(2,4-Dinitro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine (116835-05-3) → 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine (116835-06-4)

Guidance literature:

With sulfuric acid; nitric acid; at 90 ℃; for 0.5h;

DOI:10.1139/v88-074

Reference yield: 48.0%

nitromalondialdehyde sodium salt (34461-00-2) + 5-amino-3-methyl-1-(2,4-dinitrophenyl)pyrazole (91657-52-2) → 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine (116835-06-4)

Guidance literature:

zinc(II) chloride; In hydrogenchloride; ethanol; for 1h; Heating;

DOI:10.1139/v88-074

Reference yield:

1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) → 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine (116835-06-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / ZnCl₂ / aq. HCl; ethanol / 1 h / Heating

2: 82 percent / sulfuric acid, 90percent nitric acid / 0.5 h / 90 °C

3: 91 percent / sulfuric acid, 90percent nitric acid / 0.5 h / 90 °C

With sulfuric acid; nitric acid; zinc(II) chloride; In hydrogenchloride; ethanol;

DOI:10.1139/v88-074

upstream raw materials:

nitromalondialdehyde sodium salt

5-amino-3-methyl-1-(2,4-dinitrophenyl)pyrazole

1-(2,4-Dinitro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

methyl-3-pyridylketone