Synonyms:1-pyridin-3-yl-ethanone;3-acetylpyridine
99% *data from raw suppliers
3-Acetylpyridine *data from reagent suppliers
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There total 74 articles about 3-Acetylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 98.0%
Reference yield: 97.0%
Reference yield: 94.8%
The research focused on the synthesis and evaluation of imatinib mesylate (STI-571) analogs as potential agents for PET imaging of Bcr-Abl and c-KIT expression at the kinase level. The study involved molecular modeling to predict binding configurations, followed by the synthesis of STI-571 and its analogs using various reactants such as 2-methyl-5-nitroaniline, cyanamide, and 3-acetylpyridine derivatives. Radiolabeling with [18F] and [131I] was performed to prepare PET imaging agents. In vitro kinase assays were conducted to assess the potency of the analogs in inhibiting Bcr-Abl and c-KIT kinase activities. The uptake rates of [18F]-STI-571 in K562 cells (expressing Abl) and U87WT cells (overexpressing c-KIT) were measured and compared with those in U87 cells. PET scans were conducted on tumor-bearing mice to visualize tumor uptake and contrast. The research utilized various analytical techniques, including HPLC, MS, NMR, and radio-TLC, to monitor reactions, assess radiochemical purity, and characterize compounds. The results showed that the [18F]-STI-571 analog could serve as a marker for sensitivity to Bcr-Abl and c-KIT inhibitors, potentially aiding in patient selection for targeted therapies.
The research aims to develop an efficient and convenient method for synthesizing 1-N-SEM-protected 3-iodo-7-methyl-2-piperidin-3-ylindole, a compound that serves as a scaffold for creating diverse 7-methyl-substituted indole libraries with significant potential for biological activity. The study explores various synthetic steps, starting with the preparation of N-(1-pyridin-3-ylethylidene)-N-o-tolylhydrazine hydrochloride (1) through the reaction of 3-acetylpyridine and 2-methylphenylhydrazine hydrochloride. This compound is then subjected to Fischer cyclization with zinc(II) chloride in glacial acetic acid to produce 7-methyl-2-pyridin-3-yl-1H-indole (2). Subsequent selective hydrogenation using platinum(IV) oxide yields 7-methyl-2-piperidin-3-yl-1H-indole (4), which is then protected with tert-butyloxycarbonyl (Boc) to form 3-(7-methyl-1H-indol-2-yl)piperidine-1-carboxylic acid tert-butyl ester (5). The final step involves C-3 iodination followed by N-SEM protection to obtain the desired compound 3. The study concludes that this modified synthetic procedure is efficient, flexible, and convenient, requiring only moderate temperatures and providing synthetic flexibility for further chemistries at C-3 and the piperidinyl nitrogen.
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