6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Base Information

Chemical Name:6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one
CAS No.:1616831-09-4
Molecular Formula:C₃₅H₅₃F₃N₄O₅Si₂
Molecular Weight:722.996
Hs Code.:

6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Synonyms:6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

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Chemical Property of 6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

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Technology Process of 6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

There total 7 articles about 6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1616831-08-3
1-(2-(2-bromobenzyloxy)ethyl)-4-(2,2,2-trifluoroethyl)piperazine

: 1616828-84-2
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

: 1616831-09-4
6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 15h;

Reference yield:

: 1616828-60-4
6-bromo-8-(2-trimethylsilanyl-ethoxymethoxy)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-quinazolin-4-one

: 1616831-09-4
6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 15 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; In 1,4-dioxane; water;

Reference yield:

: 1215634-37-9
4-bromo-2-carboxy-6-methoxybenzenamine hydrobromide

: 1616831-09-4
6-(2-((2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethoxy)methyl)phenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 12 h / 150 °C

2: hydrogen bromide; water / acetic acid / 96 h / 130 °C

3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 80 °C / Cooling with ice

4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 15 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; hydrogen bromide; potassium acetate; sodium hydride; potassium carbonate; In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide; mineral oil;