5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Base Information

Chemical Name:5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide
CAS No.:1285514-14-8
Molecular Formula:C₂₅H₂₇N₃O₃
Molecular Weight:417.508
Hs Code.:

Synonyms:5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

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Chemical Property of 5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

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Technology Process of 5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

There total 9 articles about 5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1285514-13-7
2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2S)-2-pyrrolidinylmethyl]oxy}benzamide

: 1285514-14-8
5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: formaldehyd; 2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-{[(2S)-2-pyrrolidinylmethyl]oxy}benzamide; With formic acid; In water; at 5 ℃; Reflux;

With sodium hydrogencarbonate; In water; pH=7 - 8; Cooling;

Reference yield:

: 2150-46-1
Methyl 2,5-dihydroxybenzoate

: 1285514-14-8
5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 7 h / Reflux

2.1: Reflux

3.1: potassium hydroxide; water / ethanol / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 25 °C

5.1: sodium hydride / dimethyl sulfoxide / 0 - 20 °C

5.2: 18 h / 75 °C

6.1: trifluoroacetic acid / dichloromethane / 25 °C / Cooling with ice

6.2: pH 7 - 8

7.1: formic acid / water / 5 °C / Reflux

7.2: pH 7 - 8 / Cooling

With formic acid; water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285514-14-8
5-({[(2S)-1-methyI-2-pyrrolidinyl]methyl}oxy)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 25 °C

2.1: sodium hydride / dimethyl sulfoxide / 0 - 20 °C

2.2: 18 h / 75 °C

3.1: trifluoroacetic acid / dichloromethane / 25 °C / Cooling with ice

3.2: pH 7 - 8

4.1: formic acid / water / 5 °C / Reflux

4.2: pH 7 - 8 / Cooling

With formic acid; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;