4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine

Base Information

Chemical Name:4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine
CAS No.:1443541-32-9
Molecular Formula:C₂₀H₂₀BrClFN₃O
Molecular Weight:452.754
Hs Code.:

Synonyms:4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine

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Chemical Property of 4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine

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Technology Process of 4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine

There total 5 articles about 4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.4%

: 5414-19-7
1,1'-oxybis(2-bromo-ethane)

: 1443541-31-8
4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-amine

: 1443541-32-9
4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydroxide; In water; at 110 ℃; for 2h;

Reference yield:

: 69399-60-6
3-Bromo-5-nitro-1,2-diaminobenzene

: 1443541-32-9
4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 48 h / Reflux

1.2: 6 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

3.1: hydrogenchloride; tin(II) chloride dihdyrate / water; methanol / 3 h / 50 °C

4.1: sodium hydroxide; tetra-(n-butyl)ammonium iodide / water / 2 h / 110 °C

With hydrogenchloride; tin(II) chloride dihdyrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1443541-26-1
4-bromo-2-(fluoromethyl)-6-nitro-1H-benzo[d]imidazole

: 1443541-32-9
4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2: hydrogenchloride; tin(II) chloride dihdyrate / water; methanol / 3 h / 50 °C

3: sodium hydroxide; tetra-(n-butyl)ammonium iodide / water / 2 h / 110 °C

With hydrogenchloride; tin(II) chloride dihdyrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;