trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

Base Information

Chemical Name:trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate
CAS No.:1346763-15-2
Molecular Formula:C₃₄H₄₇ClN₂O₆S₂Si
Molecular Weight:707.427
Hs Code.:

trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

Synonyms:trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

Suppliers and Price of trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

There total 11 articles about trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1346763-13-0
N-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]acrylamide

: 1346762-52-4
trans-4-(methylamino)cyclohexyl hydroxy(di-2-thienyl)acetate

: 1346763-15-2
trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

Guidance literature:: In dichloromethane; at 75 ℃; for 64h; High pressure;

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 1346763-15-2
trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 6 h / 65 °C / High pressure

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

3: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4: N,N-diethyl-N-isopropylamine / dichloromethane / 2 h / 20 °C

5: dichloromethane / 64 h / 75 °C / High pressure

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; N,N-diethyl-N-isopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 111300-06-2
trans-tert-butyl 4-hydroxycyclohexylcarbamate

: 1346763-15-2
trans-4-((3-(4-((tert-butyl(dimethyl)silyloxy)methyl)-2-chloro-5-methoxyphenylamino)-3-oxopropyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

2: acetonitrile / 20 °C

3: sodium hydride / toluene; mineral oil / 155 °C

4: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

5: dichloromethane / 64 h / 75 °C / High pressure

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile; mineral oil;