Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

Base Information

Chemical Name:Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate
CAS No.:957065-99-5
Molecular Formula:C13H18BNO4
Molecular Weight:263.101
Hs Code.:2934999090
Mol file:957065-99-5.mol

Synonyms:5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine-2-carboxylicacid methyl ester;Methyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylate;

Suppliers and Price of Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Methoxycarbonyl-5-pyridineboronicacid,pinacolester
250mg
$ 50.00

TRC
2-Methoxycarbonyl-5-pyridineboronicacid,pinacolester
2.5g
$ 250.00

Synthonix
2-(Methylcarboxy)pyridine-5-boronicacidpinacolester 97.0%
10g
$ 460.00

SynQuest Laboratories
2-(Methylcarboxy)pyridine-5-boronic acid, pinacol ester
1 g
$ 150.00

SynQuest Laboratories
2-(Methylcarboxy)pyridine-5-boronic acid, pinacol ester
5 g
$ 520.00

Matrix Scientific
2-(Methylcarboxy)pyridine-5-boronic acid pinacol ester >95%
5g
$ 400.00

Matrix Scientific
2-(Methylcarboxy)pyridine-5-boronic acid pinacol ester >95%
1g
$ 130.00

Crysdot
Methyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate 95+%
5g
$ 222.00

Chemenu
methyl5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylate 0.95
10g
$ 500.00

AOBChem
Methylpyridine-5-boronicacidpinacolester-2-carboxylate 97%
25g
$ 660.00

Total 58 raw suppliers

Chemical Property of Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

Chemical Property:

Boiling Point:383.9 °C at 760 mmHg
PKA:1.68±0.12(Predicted)
Flash Point:186 °C
PSA：57.65000
Density:1.12 g/cm³
LogP:1.16740
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Methoxycarbonyl-5-pyridineboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

There total 2 articles about Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29682-15-3
methyl 5-bromopicolinate

: 73183-34-3
bis(pinacol)diborane

: 957065-99-5
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylic acid methyl ester

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 20 - 90 ℃; Inert atmosphere;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 957065-99-5
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilylmethyllithium / toluene / 0.5 h / -78 - 0 °C

1.2: 3 h

1.3: 18 h / 20 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.25 h / 110 °C / Sealed tube; Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; trimethylsilylmethyllithium; In 1,4-dioxane; water; toluene;
DOI:10.1016/j.ejmech.2016.11.044

Reference yield: 72.0%

: 957065-99-5
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylic acid methyl ester

: 1464153-49-8
4-(6-bromoimidazo[1,2-a]pyrazin-3-vl)benzonitrile

: 1464153-93-2
methyl 5-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)picolinate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 3h; Inert atmosphere;