(-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

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Chemical Name:(-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone
CAS No.:1247052-99-8
Molecular Formula:C₃₄H₅₄N₄O₆Si
Molecular Weight:642.911
Hs Code.:

(-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Synonyms:(-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

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Chemical Property of (-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

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Technology Process of (-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

There total 8 articles about (-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1247052-99-8
(-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Guidance literature:

Reference yield: 57.0%

: 1247052-93-2
S-(S)-1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-(tert-butyldimethylsilyloxy)-6-oxooctan-3-yl O-ethyl carbonodithioate

: 1247052-99-8
(-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Guidance literature:: With dilauryl peroxide; In isopropyl alcohol; for 5h; Reflux; Inert atmosphere;
DOI:10.1021/jo4001492

Reference yield:

: 156093-90-2
(S)-3-[(tert-butyldimethyl)silyloxy]-1-chlorobutan-2-one

: 1247052-99-8
(-)-(3S,9S,14aR)-9-benzyl-3-[(S)-7-(tert-butyldimethylsilyloxy)-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetone / 4 h / 0 - 20 °C / Inert atmosphere

2.1: 1,2-dichloro-ethane / 0.5 h / Inert atmosphere; Reflux

2.2: Inert atmosphere; Reflux

3.1: dilauryl peroxide / isopropyl alcohol / 5 h / Reflux; Inert atmosphere

With dilauryl peroxide; In 1,2-dichloro-ethane; isopropyl alcohol; acetone;
DOI:10.1021/jo4001492