2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid

Base Information

Chemical Name:2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid
CAS No.:118388-00-4
Molecular Formula:C₂₈H₂₇NO₇
Molecular Weight:489.525
Hs Code.:

Synonyms:2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid

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Chemical Property of 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid

Chemical Property:

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Technology Process of 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid

There total 4 articles about 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid dibenzyl ester

: 118388-00-4
2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h;
DOI:10.1021/jm00164a058

Reference yield:

: 19317-12-5,19317-09-0
(3S)-3-(N-benzyloxycarbonylamino)-3-benzyl-2-oxo-1-bromopropane

: 118388-00-4
2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h

2: 1.) NaH / 1.) DMSO, 1 h, 2.) 24 h

3: H₂ / 20percent Pd/C / methanol / 3 h

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00164a058

Reference yield:

: 15196-02-8
(S)-3-[(benzyloxycarbonyl)amino]-1-diazo-4-phenyl-2-butanone

: 118388-00-4
2-Benzyl-2-((S)-3-benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: HBr gas / diethyl ether / -20 °C

2: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) a) 0 deg C, 0.5 h, b) room temp., 1 h

3: 1.) NaH / 1.) DMSO, 1 h, 2.) 24 h

4: H₂ / 20percent Pd/C / methanol / 3 h

With hydrogen bromide; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1021/jm00164a058