Carbamic acid, [(1S)-3-bromo-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-3-bromo-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester
CAS No.:19317-12-5
Molecular Formula:C18H18BrNO3
Molecular Weight:376.25
Hs Code.:
Mol file:19317-12-5.mol

Synonyms:(S)-benzyl (4-bromo-3-oxo-1-phenylbutan-2-yl)carbamate;(S)-3-benzyloxycarbonylamino-4-phenyl-2-oxo-1-bromobutane;(3-bromo-1-(S)-benzyl-2-oxopropyl)carbamic acid benzyl ester;(S)-benzyl-(4-bromo-3-oxo-1-phenylbutan-2-yl)carbamate;((S)-1-Benzyl-3-bromo-2-oxo-propyl)-carbamic acid benzyl ester;N-α-Cbz-phenylalanylbromomethylketone;[N-(benzyloxycarbonyl)-L-phenylalanyl]methyl bromide;

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Chemical Property of Carbamic acid, [(1S)-3-bromo-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester

Chemical Property:

Melting Point:102-103 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
Boiling Point:522.2±50.0 °C(Predicted)
PSA：55.40000
Density:1.383±0.06 g/cm3(Predicted)
LogP:3.87900

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-3-bromo-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester

There total 11 articles about Carbamic acid, [(1S)-3-bromo-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 15196-02-8
(S)-3-[(benzyloxycarbonyl)amino]-1-diazo-4-phenyl-2-butanone

: 19317-12-5,19317-09-0
(3S)-3-(N-benzyloxycarbonylamino)-3-benzyl-2-oxo-1-bromopropane

Guidance literature:: With hydrogen bromide; acetic acid; for 1h;
DOI:10.1016/j.tetasy.2005.01.049

Reference yield: 84.0%

: 191226-91-2
4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

: 19317-12-5,19317-09-0
(3S)-3-(N-benzyloxycarbonylamino)-3-benzyl-2-oxo-1-bromopropane

Guidance literature:: With trifluoroacetic acid; In benzene; for 2h; Heating;
DOI:10.1021/jo010319h

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 19317-12-5,19317-09-0
(3S)-3-(N-benzyloxycarbonylamino)-3-benzyl-2-oxo-1-bromopropane

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / diethyl ether; tetrahydrofuran / 0.5 h / -25 °C

2: diethyl ether / 3 h / -10 °C

3: hydrobromic acid; AcOH / 1 h / 20 °C

With hydrogen bromide; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether;
DOI:10.3390/12051183