(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane

Base Information

Chemical Name:(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane
CAS No.:763126-75-6
Molecular Formula:C₂₈H₃₄O₂Si
Molecular Weight:430.662
Hs Code.:

Synonyms:(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane

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Technology Process of (1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane

There total 1 articles about (1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625389-71-1
(+)-(1R,2S)-(2-hydroxymethyl-1-phenyl-cyclopropyl)-methanol

: 763126-75-6
(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / -20 °C

1.2: 25 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 °C

2.1: 96 mg / tetrahydrofuran / 8 h / -78 °C

With sodium hydride; In tetrahydrofuran; 1.2: Swern oxidation / 2.1: Grignard addition;
DOI:10.1016/j.tet.2004.05.063

Reference yield: 99.0%

: 17257-71-5,20445-31-2,56135-03-6,81655-41-6
(S)-Mosher acid

: 763126-75-6
(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane

: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-[(1S,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2004.05.063

Reference yield: 97.0%

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 763126-75-6
(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-[(S)-1-hydroxyethyl]-1-phenylcyclopropane

: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-[(1S,2R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2004.05.063