N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide

Base Information

Chemical Name:N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide
CAS No.:1015169-89-7
Molecular Formula:C₂₃H₂₈ClN₅O₂S
Molecular Weight:474.027
Hs Code.:

Synonyms:N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide

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Chemical Property of N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide

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Technology Process of N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide

There total 5 articles about N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1015170-86-1
8-benzyl-2,3,8-triaza-spiro[4.5]dec-2-ene

: 1015169-89-7
N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / Inert atmosphere; Reflux

2: methanol; water / 1 h / 20 °C / Inert atmosphere

With pyridine; In methanol; water;
DOI:10.1021/jm200466r

Reference yield:

: 100-39-0
benzyl bromide

: 1015169-89-7
N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C / Inert atmosphere

2.2: 65 °C

3.1: lithium aluminium tetrahydride / cyclopentyl methyl ether / 20 °C / Inert atmosphere; Cooling with ice

4.1: sodium hypochlorite; dihydrogen peroxide / methanol; water / 20 °C / Inert atmosphere; Cooling with ice

5.1: pyridine / Inert atmosphere; Reflux

6.1: methanol; water / 1 h / 20 °C / Inert atmosphere

With pyridine; sodium hypochlorite; lithium aluminium tetrahydride; dihydrogen peroxide; potassium carbonate; In methanol; cyclopentyl methyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200466r

Reference yield:

: 52419-85-9
(4-(aminomethyl)-1-benzylpiperidin-4-yl)methanamine

: 1015169-89-7
N-[ethylamino-(8-benzyl-2,3,8-triaza-spiro[4.5]dec-3-en-2-yl)methylidene]-3-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hypochlorite; dihydrogen peroxide / methanol; water / 20 °C / Inert atmosphere; Cooling with ice

2: pyridine / Inert atmosphere; Reflux

3: methanol; water / 1 h / 20 °C / Inert atmosphere

With pyridine; sodium hypochlorite; dihydrogen peroxide; In methanol; water;
DOI:10.1021/jm200466r