2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione
• CAS No.: 171368-34-6
• Molecular Formula: C₂₂H₁₂N₂O₅
• Molecular Weight: 384.348
• Mol file: 171368-34-6.mol

Synonyms:2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione

Chemical Property of 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione

There total 1 articles about 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione (171368-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) acetic anhydride, pyridine / 1.) DMF, 25 deg C, 1 h, 2.) DMF, 90 deg C, 5 h

2: 99 percent / boron tribromide / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) RT, 12 h

With pyridine; acetic anhydride; boron tribromide; In dichloromethane;

DOI:10.1021/ja00152a008

Reference yield: 87.0%

2-(Ethyl-{4-[5-(4-nitro-phenyl)-thiophen-2-yl]-phenyl}-amino)-ethanol (171368-23-3) + 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione (171368-34-6) → C42H30N4O7S (171368-24-4)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; triphenylphosphine; diethylazodicarboxylate; for 8h; Ambient temperature;

DOI:10.1021/ja00152a008

Reference yield: 81.0%

2-(ethyl(4-(2-(4-nitrophenyl)ethenyl)phenyl)amino)ethanol (122258-56-4) + 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-hydroxyphenyl]-1H-isoindole-1,3(2H)-dione (171368-34-6) → C40H30N4O7

Guidance literature:

With 1-methyl-pyrrolidin-2-one; triphenylphosphine; diethylazodicarboxylate; for 8h; Ambient temperature;

DOI:10.1021/ja00152a008

upstream raw materials:

phthalic anhydride

Downstream raw materials:

C₄₂H₃₀N₄O₇S

benzyl 7-{[(benzyloxy)carbonyl]amino}-3-methyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate

benzyl (3S)-7-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-3-methyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate