(R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol

Base Information

Chemical Name:(R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol
CAS No.:1617545-57-9
Molecular Formula:C₁₅H₁₇ClFN₃O
Molecular Weight:309.771
Hs Code.:

Synonyms:(R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol

Suppliers and Price of (R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol

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Technology Process of (R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol

There total 2 articles about (R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 1617545-61-5
2-chloro-6-(5-chloro-2-fluorophenyl)-pyrazine

: 1617545-57-9
(R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol

Guidance literature:: at 80 ℃; for 1.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 352535-83-2
5-chloro-2-fluorophenylboronic acid

: 1617545-57-9
(R)-2-[6-(5-chloro-2-fluoro-phenyl)-pyrazin-2-ylamino]-3-methyl-butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2: 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; N,N-dimethyl-formamide;