tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate

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Chemical Name:tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate
CAS No.:1197291-49-8
Molecular Formula:C₃₆H₄₆FN₅O₅
Molecular Weight:647.79
Hs Code.:

Synonyms:tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate

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Chemical Property of tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate

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Technology Process of tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate

There total 6 articles about tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1197291-48-7
tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-3'-hydroxybiphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

: 21655-48-1,1013625-96-1
cis-2,6-dimethylpiperazine

: 1197291-49-8
tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate

Guidance literature:: tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-3'-hydroxybiphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate; cis-2,6-dimethylpiperazine; In dichloromethane; at 18 - 25 ℃; for 2h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 1h; Inert atmosphere;
DOI:10.1021/jm5001216

Reference yield:

: 1196806-69-5
tert-butyl N-[(1s,4s)-4-[5-fluoro-2-(3-iodophenoxy)nicotinamido]cyclohexyl]carbamate

: 1197291-49-8
tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 18 h / 70 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 18 - 25 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm5001216

Reference yield:

: 38186-88-8
2-chloro-5-fluoronicotinic acid

: 1197291-49-8
tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-3'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile; tetrahydrofuran / 0 - 25 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 18 h / 70 °C / Inert atmosphere

5.1: dichloromethane / 2 h / 18 - 25 °C / Inert atmosphere

5.2: 1 h / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm5001216