4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole

Base Information

Chemical Name:4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole
CAS No.:1352816-53-5
Molecular Formula:C₂₅H₃₆N₂O₂S
Molecular Weight:428.639
Hs Code.:

Synonyms:4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole

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Chemical Property of 4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole

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Technology Process of 4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole

There total 4 articles about 4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1193-12-0
3,3-dimethylpiperidine

: 1352816-48-8
4-(3-bromopropyl)-1-tosyl-1H-4,5,6,7-tetrahydroindole

: 1352816-53-5
4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole

Guidance literature:: With sodium carbonate; In acetonitrile; Reflux;
DOI:10.1016/j.bmc.2011.10.023

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1352816-53-5
4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / water; toluene / 0.17 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: magnesium

3.1: sodium carbonate / acetonitrile / Reflux

With tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; magnesium; potassium hydroxide; In water; toluene; acetonitrile; 2.2: Grignard reaction;
DOI:10.1016/j.bmc.2011.10.023

Reference yield:

: 35577-89-0
1-[(4-methylbenzene)sulfonyl]-4,5,6,7-tetrahydro-1H-indol-4-one

: 1352816-53-5
4-[3-(3,3-dimethylpiperidin-1-yl)propyl]-1-tosyl-1H-4,5,6,7-tetrahydroindole

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium

2: sodium carbonate / acetonitrile / Reflux

With sodium carbonate; magnesium; In acetonitrile; 1: Grignard reaction;
DOI:10.1016/j.bmc.2011.10.023