35577-89-0

Basic information

• Product Name: 1-Tosyl-6,7-dihydro-1H-indole-4(5H)-one
• Synonyms: 1-[(4-Methylphenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-indol-4-one;1-Tosyl-6,7-dihydro-1H-indole-4(5H)-one;4-Oxo-1-tosyl-4,5,6,7-tetrahydro-1H-indole;1-(Toluene-4-sulfonyl)-1,5,6,7-tetrahydro-indol-4-one
• CAS NO: 35577-89-0
• Molecular Formula: C₁₅H₁₅NO₃S
• Molecular Weight: 289.35
• Mol File: 35577-89-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Tosyl-6,7-dihydro-1H-indole-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Tosyl-6,7-dihydro-1H-indole-4(5H)-one(35577-89-0)
• EPA Substance Registry System: 1-Tosyl-6,7-dihydro-1H-indole-4(5H)-one(35577-89-0)

Safety Data

• Hazardous Substances Data: 35577-89-0(Hazardous Substances Data)

Usage

Structure

A tosyl derivative of indole, a bicyclic compound consisting of a benzene ring fused to a pyrrole ring, with a tosyl group (a sulfonamide group) attached to the nitrogen atom of the pyrrole ring.

Uses

A key intermediate in the synthesis of various pharmaceutical compounds, with potential applications in the development of new drugs for the treatment of viral and malarial infections. It is also used in the production of dyes and pigments, as well as in organic synthesis.

Properties

Exhibits anti-viral and anti-malarial properties.

Upstream product

• 107-20-0 2-chloroethanal 
• 504-02-9 1,3-cylohexanedione 
• 98-59-9 p-toluenesulfonyl chloride 
• 127-65-1 chloroamine-T 
• 13754-86-4 1,5,6,7-tetrahydro-indol-4-one 
• 104-15-4 toluene-4-sulfonic acid 
• 76988-93-7 C₂₁H₂₈N₂O₄S 

Downstream Products

• 106154-13-6 1-[(4-methylbenzene)sulfonyl]-4-[(trimethylsilyl)oxy]-4,5,6,7-tetrahydro-1H-indole-4-carbonitrile 
• 113484-99-4 4-Methanesulfonylmethyl-1-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-1H-indol-4-ol 
• 107170-55-8 [1-(Toluene-4-sulfonyl)-1,5,6,7-tetrahydro-indol-(4Z)-ylidene]-acetonitrile 
• 107196-76-9 [1-(Toluene-4-sulfonyl)-1,5,6,7-tetrahydro-indol-(4E)-ylidene]-acetonitrile 
• 106507-71-5 4-bis-(phenylthio)methyl-4-hydroxy-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole 
• 113484-98-3 4-Benzenesulfonylmethyl-1-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-1H-indol-4-ol 
• 107170-65-0 4-(3-methylbut-2-enylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole 
• 95969-07-6 5-chloro-4-oxo-N-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole 
• 76989-06-5 5-bromo-4-oxo-N-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole 
• 95969-12-3 2-chloro-4-oxo-N-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole 
• 95969-11-2 5,5-dibromo-4-oxo-N-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole 
• 175227-87-9 Trifluoro-methanesulfonic acid 1-(toluene-4-sulfonyl)-6,7-dihydro-1H-indol-4-yl ester 
• 261352-44-7 1-methoxy-2-(4-hydroxy-1-tosyl-4,5,6,7-tetrahydro-1H-indol-4-yl)-1H-indole 
• 261352-45-8 1-methoxy-2-(1-tosyl-6,7-dihydro-1H-indol-4-yl)-1H-indole 

Relevant articles and documents

Synthesis and Spectroscopic Properties of 1,2,3-Triazole BOPAHY Dyes and Their Water-Soluble Triazolium Salts

Water-soluble BOPAHY fluorophores have not yet been reported. The potential of 1,2,3-triazolium salts for the formation of water-soluble chromophores is explored. 1,2,3-Triazole-substituted pyrroles were synthesized in a metal-free pathway and alkylated t

PYRANOPYRAZOLE AND PYRAZOLOPYRIDINE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: (I), (II) These compounds inhibit Coagulation Factor Xlla in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.

Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands

Starting from two carbocyclic analogs, a series of 3,3-dimethylpiperidine derivatives was prepared and tested in radioligand binding assays at σ1 and σ2 receptors, and at Δ8-Δ7 sterol isomerase (SI) site. The novel compounds mostly bear heterocyclic rings or bicyclic nucleus of differing lipophilicities. Compounds 18a and 19a,b demonstrated the highest σ1 affinity (Ki = 0.14-0.38 nM) with a good selectivity versus σ2 binding. Among them, 18a had the lowest C log D value (3.01) and only 19b was selective versus SI too. Generally, it was observed that more planar and hydrophilic heteronuclei conferred a decrease in affinity for both σ receptor subtypes.