Technology Process of (4aR,4bS,7S,8aR,10aR)-7-Benzyloxy-4b,8,8,10a-tetramethyl-1-phenylsulfanyl-dodecahydro-phenanthren-2-one
There total 9 articles about (4aR,4bS,7S,8aR,10aR)-7-Benzyloxy-4b,8,8,10a-tetramethyl-1-phenylsulfanyl-dodecahydro-phenanthren-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: NaBH4 / methanol / -78 °C
2: NaH / dimethylformamide / 2 h / 25 °C
3: 1.) BH3, 2.) pyridinium chlorochromate (PCC) / 1.) THF, 24 deg C, 4 h, 2.) CH2Cl2, 1.5 h
4: tetrahydrofuran / 2 h / 0 - 24 °C
5: hexamethylphosphoric acid triamide / 1 h / 210 °C
6: 1.) BH3 / 1.) THF, 15 deg C, 12 h, 2.) PhMe, 12 atm, 6 h
7: tetrahydrofuran / 3 h / -10 °C
8: SiO2
With
sodium tetrahydroborate; borane; silica gel; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1021/ja00077a073
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 3-tert-butyl-4-hydroxy-5-methylphenyl sulfide (BMPS) / 3 h / 350 °C / 40 Torr
2: NaBH4 / methanol / -78 °C
3: NaH / dimethylformamide / 2 h / 25 °C
4: 1.) BH3, 2.) pyridinium chlorochromate (PCC) / 1.) THF, 24 deg C, 4 h, 2.) CH2Cl2, 1.5 h
5: tetrahydrofuran / 2 h / 0 - 24 °C
6: hexamethylphosphoric acid triamide / 1 h / 210 °C
7: 1.) BH3 / 1.) THF, 15 deg C, 12 h, 2.) PhMe, 12 atm, 6 h
8: tetrahydrofuran / 3 h / -10 °C
9: SiO2
With
sodium tetrahydroborate; 6,6'-di-tert-butyl-4,4'-thiodi-o-cresol; borane; silica gel; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1021/ja00077a073
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151702-19-1
(3S,4aR,8aS)-3-Benzyloxy-4,4,7,8a-tetramethyl-8-vinyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) BH3 / 1.) THF, 15 deg C, 12 h, 2.) PhMe, 12 atm, 6 h
2: tetrahydrofuran / 3 h / -10 °C
3: SiO2
With
borane; silica gel;
In
tetrahydrofuran;
DOI:10.1021/ja00077a073
