2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol

Base Information

Chemical Name:2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol
CAS No.:1442090-03-0
Molecular Formula:C₂₈H₄₁N₃O₅Si
Molecular Weight:527.736
Hs Code.:

Synonyms:2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol

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Chemical Property of 2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol

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Technology Process of 2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol

There total 9 articles about 2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1442090-02-9
2-C-azidomethyl-5-O-benzhydryl-2,3-O-isopropylidene-D-ribitol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1442090-03-0
2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 5h;
DOI:10.1021/jo4005487

Reference yield:

: C₂₃H₂₃F₃O₈S

: 1442090-03-0
2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

2: sodium tetrahydroborate / tert-butyl alcohol; ethanol / 1.5 h / 20 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium azide; In ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo4005487

Reference yield:

: 1442089-94-2
C₂₂H₂₄O₆

: 1442090-03-0
2-C-azidomethyl-5-O-benzhydryl-1-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribitol

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 1 h / -30 - -10 °C

2: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

3: sodium tetrahydroborate / tert-butyl alcohol; ethanol / 1.5 h / 20 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium azide; In ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo4005487