(+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one

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Chemical Name:(+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one
CAS No.:96326-26-0
Molecular Formula:C₂₄H₃₆N₂O₈Si
Molecular Weight:508.644
Hs Code.:

Synonyms:(+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one

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Chemical Property of (+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one

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Technology Process of (+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one

There total 6 articles about (+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32296-85-8
ethyl 3,3-(ethylenedioxy)-4-formylbutyrate

: 96326-26-0
(+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: benzene / 1 h / 50 °C

2: 22.7 percent / benzene / 16 h / Heating

3: H₂, AcOH / 10percent Pd/C / 38 h / 3420 Torr / Ambient temperature

4: N,N'-dicyclohexylcarbodiimide / acetonitrile / 3 h / 60 °C

5: 57.8 percent / Et₃N / dimethylformamide / 18 h / Ambient temperature

6: 1.) aq. NaOH / 1.) THF, RT, 2 h, 2.) DMF, RT, 2 h

With sodium hydroxide; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00213a025

Reference yield:

: 96347-28-3
benzyl (-)-(3,4-cis,4,5-trans)-3-<3-(ethoxycarbonyl)-2,2-(ethylenedioxy)propyl>-5-methyl-2-((1S)-1-phenylethyl)isoxazolidine-4-carboxylate

: 96326-26-0
(+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, AcOH / 10percent Pd/C / 38 h / 3420 Torr / Ambient temperature

2: N,N'-dicyclohexylcarbodiimide / acetonitrile / 3 h / 60 °C

3: 57.8 percent / Et₃N / dimethylformamide / 18 h / Ambient temperature

4: 1.) aq. NaOH / 1.) THF, RT, 2 h, 2.) DMF, RT, 2 h

With sodium hydroxide; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00213a025

Reference yield:

: 96326-21-5
C₁₇H₂₃NO₅

: 96326-26-0
(+)-3α-<(1R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-4β-<3-<<(p-nitrobenzyl)oxy>carbonyl>-2,2-(ethylenedioxy)propyl>azetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 22.7 percent / benzene / 16 h / Heating

2: H₂, AcOH / 10percent Pd/C / 38 h / 3420 Torr / Ambient temperature

3: N,N'-dicyclohexylcarbodiimide / acetonitrile / 3 h / 60 °C

4: 57.8 percent / Et₃N / dimethylformamide / 18 h / Ambient temperature

5: 1.) aq. NaOH / 1.) THF, RT, 2 h, 2.) DMF, RT, 2 h

With sodium hydroxide; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00213a025