1-Boc-4-bromo-2-indoleboronic acid

Base Information

• Chemical Name: 1-Boc-4-bromo-2-indoleboronic acid
• CAS No.: 957034-29-6
• Molecular Formula: C13H15 B Br N O4
• Molecular Weight: 339.981
• Hs Code.: 2933990090
• Mol file: 957034-29-6.mol

Synonyms:1-Boc-4-bromo-2-indoleboronic acid;1-Boc-4-bromo-indole-2-boronic acid;4-Bromo-1-(tert-butoxycarbonyl)-1H-indol-2-ylboronic acid;1H-Indole-1-carboxylic acid, 2-borono-4-bromo-, 1-(1,1-dimethylethyl) ester

Chemical Property of 1-Boc-4-bromo-2-indoleboronic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.577
• Boiling Point: 488.289°C at 760 mmHg
• Flash Point: 249.108°C
• PSA: 71.69000
• Density: 1.451g/cm³
• LogP: 1.86680
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-BOC-4-bromo-indole-2-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-bromo-2-indoleboronic acid

There total 1 articles about 1-Boc-4-bromo-2-indoleboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromoindole-1-carboxylic acid tert-butyl ester (676448-17-2) → 4-bromo-1-(tert-butoxycarbonyl)-1H-indol-2-ylboronic acid (957034-29-6)

Guidance literature:

4-bromoindole-1-carboxylic acid tert-butyl ester; With Triisopropyl borate; lithium diisopropyl amide; In tetrahydrofuran; at 0 - 5 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1016/j.tet.2009.06.071

Reference yield: 60.0%

4-acetylbenzyl bromide (51229-51-7) + 4-bromo-1-(tert-butoxycarbonyl)-1H-indol-2-ylboronic acid (957034-29-6) → 2-(4-acetyl-benzyl)-4-bromo-indole-1-carboxylic acid tert-butyl ester (1227625-72-0)

Guidance literature:

With trans-bromo(N-succinimidyl)-bis(triphenylphosphine)palladium(II); sodium carbonate; In tetrahydrofuran; at 60 ℃; for 1h;

DOI:10.1016/j.tetlet.2010.02.124

Reference yield: 60.0%

4-bromo-1-(tert-butoxycarbonyl)-1H-indol-2-ylboronic acid (957034-29-6) + 1-(Bromomethyl)-3-fluorobenzene (456-41-7) → 4-bromo-2-(3-fluoro-benzyl)-indole-1-carboxylic acid tert-butyl ester (1227625-71-9)

Guidance literature:

With trans-bromo(N-succinimidyl)-bis(triphenylphosphine)palladium(II); sodium carbonate; In tetrahydrofuran; at 60 ℃; for 1h;

DOI:10.1016/j.tetlet.2010.02.124

upstream raw materials:

4-bromoindole-1-carboxylic acid tert-butyl ester

Downstream raw materials:

dimethyl 2-(2-((4-bromo-1-(tert-butoxycarbonyl)-1H-indol-2-yl)methyl)benzylidene)malonate

2-(4-acetyl-benzyl)-4-bromo-indole-1-carboxylic acid tert-butyl ester

4-bromo-2-(3-fluoro-benzyl)-indole-1-carboxylic acid tert-butyl ester

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