{4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone

Base Information

Chemical Name:{4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone
CAS No.:1314882-87-5
Molecular Formula:C₂₃H₂₀F₃N₃O₂
Molecular Weight:427.426
Hs Code.:

Synonyms:{4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone

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Technology Process of {4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone

There total 5 articles about {4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1416315-09-7
(4-(6-amino-5-bromopyridin-3-yl)phenyl)(morpholino)methanone

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1314882-87-5
{4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 14h; Inert atmosphere;
DOI:10.1021/jm301476b

Reference yield:

: 389621-84-5
4-(morpholine-4-carbonyl)phenylboronic acid

: 1314882-87-5
{4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 14 h / 90 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 14 h / 90 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; 1: |Suzuki Coupling / 2: |Suzuki Coupling;
DOI:10.1021/jm301476b

Reference yield:

: 697300-73-5
2-amino-3-bromo-5-iodopyridine

: 1314882-87-5
{4-[2-amino-3-(4-(trifluoromethyl)phenyl)pyridin-5-yl]phenyl}(morpholino)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 14 h / 90 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 14 h / 90 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; 1: |Suzuki Coupling / 2: |Suzuki Coupling;
DOI:10.1021/jm301476b