(S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester

Base Information

• Chemical Name: (S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester
• CAS No.: 215182-81-3
• Molecular Formula: C₃₀H₃₄NO₆P
• Molecular Weight: 535.577

Synonyms:(S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester

Chemical Property of (S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester

Chemical Property:

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Technology Process of (S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester

There total 1 articles about (S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester (120230-41-3) + dimethyl methane phosphonate (756-79-6) → (S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester (215182-81-3)

Guidance literature:

With n-butyllithium; In hexane; toluene; at -78 ℃; for 1h; Product distribution; other solvent;

DOI:10.1021/jo9814602

Reference yield: 69.0%

isovaleraldehyde (590-86-3) + (S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester (215182-81-3) → (2S,5E)-tert-butyl 8-methyl-4-oxo-[N-(9-(9-phenylfluorenyl))amino]-non-5-enoate (489429-08-5)

Guidance literature:

With caesium carbonate; In acetonitrile; for 15h;

Reference yield: 67.0%

tert-butyl (2S)-2-[(9-phenyl-9-fluorenyl)amino]-4-oxobutanoate (215182-76-6) + (S)-5-(Dimethoxy-phosphoryl)-4-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-pentanoic acid tert-butyl ester (215182-81-3) → (2S,5E,8S)-di-tert-butyl 4-oxo-2,8-bis-[N-(9-(9-phenylfluorenyl))amino]non-5-enedioate (215182-85-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 25 ℃; for 72h;

DOI:10.1021/jo9814602

upstream raw materials:

N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester

dimethyl methane phosphonate

Downstream raw materials:

(2S,5E,8S)-di-tert-butyl 4-oxo-2,8-bis-[N-(9-(9-phenylfluorenyl))amino]non-5-enedioate

(2S,5E)-tert-butyl 8-methyl-4-oxo-[N-(9-(9-phenylfluorenyl))amino]-non-5-enoate

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