(4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone

Base Information

Chemical Name:(4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone
CAS No.:1622426-41-8
Molecular Formula:C₂₁H₂₂N₄O
Molecular Weight:346.432
Hs Code.:

Synonyms:(4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone

Suppliers and Price of (4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone

There total 3 articles about (4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53355-55-8
pyrazole-1-carbonyl chloride

: 84359-51-3
1-([1,1'-biphenyl]-4-ylmethyl)piperazine

: 1622426-41-8
(4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.06.063

Reference yield:

: 1322768-09-1
tert-butyl 4-([1,1'-biphenyl]-4-ylmethyl)piperazine-1-carboxylate

: 1622426-41-8
(4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2014.06.063

Reference yield:

: 2567-29-5
p-phenylbenzyl bromide

: 1622426-41-8
(4-([1,1'-biphenyl]-4-ylmethyl)piperazin-1-yl)(1H-pyrazol-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2014.06.063