C₃₉H₅₇N₃O₁₁Si₂

Base Information

• Chemical Name: C₃₉H₅₇N₃O₁₁Si₂
• CAS No.: 175441-53-9
• Molecular Formula: C₃₉H₅₇N₃O₁₁Si₂
• Molecular Weight: 800.066
• Mol file: 175441-53-9.mol

Synonyms:C₃₉H₅₇N₃O₁₁Si₂

Chemical Property of C₃₉H₅₇N₃O₁₁Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₃₉H₅₇N₃O₁₁Si₂

There total 4 articles about C₃₉H₅₇N₃O₁₁Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

methyl chloroformate (79-22-1) + C37H55N3O9Si2 (175523-43-0) → C39H57N3O11Si2 (175441-53-9)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jo952067o

Reference yield:

7-(triethylsilyl)baccatin III (115437-21-3) → C39H57N3O11Si2 (175441-53-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) imidazole, 2.) imidazole / 1.) DMF, 0 deg C, 1.5 h, 2.) 0 deg C, 1 h

2: 58 percent / Red-Al / tetrahydrofuran / 0.67 h / 0 °C

3: 1.) triphenylphosphine, carbon tetrachloride, 2.) NaN₃ / 1.) dichloromethane, 0 deg C, 1 h, 2.) DMF, 40 deg C, 2 h

4: 28 percent / LiHMDS / tetrahydrofuran / 1 h / 0 °C

With 1H-imidazole; tetrachloromethane; sodium azide; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jo952067o

Reference yield:

4-deacetyl-1-dimethylsilyl-7-triethylsilylbaccatin III (175441-49-3) → C39H57N3O11Si2 (175441-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) triphenylphosphine, carbon tetrachloride, 2.) NaN₃ / 1.) dichloromethane, 0 deg C, 1 h, 2.) DMF, 40 deg C, 2 h

2: 28 percent / LiHMDS / tetrahydrofuran / 1 h / 0 °C

With tetrachloromethane; sodium azide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jo952067o

upstream raw materials:

methyl chloroformate

C₃₇H₅₅N₃O₉Si₂

7-(triethylsilyl)baccatin III

4-deacetyl-1-dimethylsilyl-7-triethylsilylbaccatin III

Downstream raw materials:

C₃₉H₅₉NO₁₁Si₂