175441-49-3

Upstream product

• 175441-47-1 C₄₂H₆₆O₁₁Si₃ 
• 160582-74-1 1-dimethylsilyl-7,13-bis(triethylsilane)baccatin III 
• 115437-21-3 7-(triethylsilyl)baccatin III 

Downstream Products

• 175523-43-0 C₃₇H₅₅N₃O₉Si₂ 
• 175441-57-3 C₃₇H₅₃NO₁₀Si 
• 175441-53-9 C₃₉H₅₇N₃O₁₁Si₂ 
• 175441-54-0 C₃₉H₅₉NO₁₁Si₂ 
• 175441-55-1 13-α-azido-7-(triethylsilyl)-A-nor-baccatin III 
• 175441-56-2 C₃₇H₅₁N₃O₁₀Si 
• 175441-51-7 C₃₇H₅₇NO₉Si₂ 

Relevant academic research and scientific papers

Synthesis of 4-deacetyl-1-dimethylsilyl-7-triethylsilylbaccatin III

A one-pot trisilylation step to protect three hydroxyl groups of baccatin III (1), followed by hydride ester cleavage and base hydrolysis of a triethylsilyl ether at C13, provides efficient access to a key intermediate 9 (top path). This route removes two

Synthesis and biological evaluation of C-13 amide-linked paclitaxel (Taxol) analogs

Several C-13 amidopaclitaxel analogs have been synthesized during the course of our structure-activity relationship study at the C-13 position. These include 4-deacetyl-13-amidopaclitaxel (4), 13-amidopaclitaxel 4-(methyl carbonate) derivatives (5a,b), and 13-amidopaclitaxel (6). None of these novel C-13 amidopaclitaxel analogs retain any activity in the tubulin polymerization assay or the in vitro cytotoxicity assay.