4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol

Base Information

Chemical Name:4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol
CAS No.:700813-13-4
Molecular Formula:C₂₀H₂₃N₃O₃
Molecular Weight:353.421
Hs Code.:

Synonyms:4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol

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Chemical Property of 4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol

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Technology Process of 4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol

There total 14 articles about 4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5-(4-(benzyloxy)-3-methoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-amine

: 700813-13-4
4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; acetic acid; at 20 ℃; for 24h;
DOI:10.3390/md16090311

Reference yield: 95.0%

: 700813-13-4
4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 20 ℃; for 24h;

Reference yield:

: 2-acetamido-3-(4-(benzyloxy)-3-methoxyphenyl)propanoic acid

: 700813-13-4
4-((4-(4-methoxybenzyl)-2-amino-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / 24 h / Reflux

2.1: triethylamine / water; 1,4-dioxane / 18 h / 20 °C

3.1: potassium carbonate / methanol / 4 h / Reflux

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 24 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

6.1: magnesium / tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

6.2: 3 h / 0 - 20 °C / Inert atmosphere

7.1: acetyl chloride / ethanol; diethyl ether / 1.17 h / -30 - 20 °C

8.1: water / 1 h / 90 °C

9.1: palladium 10% on activated carbon; hydrogen / methanol; acetic acid / 24 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; acetic acid;
DOI:10.3390/md16090311