3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid

Base Information

Chemical Name:3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid
CAS No.:1370748-98-3
Molecular Formula:C₂₃H₂₁N₅O₆
Molecular Weight:463.45
Hs Code.:

Synonyms:3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid

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Chemical Property of 3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid

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Technology Process of 3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid

There total 5 articles about 3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1312592-14-5
C₁₃H₁₃NO₃

: 1370749-07-7
3-azido-3-(benzo[d]oxazol-2-yl)propanoic acid

: 1370748-98-3
3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid

Guidance literature:: With triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm201496g

Reference yield:

: C₁₀H₁₀N₂O₃

: 1370748-98-3
3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

2: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm201496g

Reference yield:

: 1370749-25-9
tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate

: 1370748-98-3
3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: hydrogenchloride / 1,4-dioxane; water; ethyl acetate / 0 - 20 °C

3.1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

4.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jm201496g