tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate

Base Information

Chemical Name:tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate
CAS No.:1370749-25-9
Molecular Formula:C₁₉H₂₈N₂O₆
Molecular Weight:380.441
Hs Code.:

Synonyms:tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate

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Chemical Property of tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate

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Technology Process of tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate

There total 1 articles about tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1676-90-0
N-Boc-DL-aspartic acid 1-tert-butyl ester

: 95-55-6
2-amino-phenol

: 1370749-25-9
tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm201496g

Reference yield:

: 1370749-25-9
tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate

: 1370748-98-3
3-(4-((E)-2-(4-methoxybenzyloxycarbamoyl)vinyl)-1H-1,2,3-triazol-1-yl)-3-(benzo[d]oxazol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere

1.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: hydrogenchloride / 1,4-dioxane; water; ethyl acetate / 0 - 20 °C

3.1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h

4.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jm201496g