Technology Process of tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate
There total 1 articles about tert-butyl N-[1-(2-hydroxyphenylcarbamoyl)-2-(tert-butoxycarbonyl)ethyl]carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jm201496g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine / tetrahydrofuran / 1 h / 0 °C / Molecular sieve; Inert atmosphere
1.2: 8 h / 20 °C / Inert atmosphere; Molecular sieve
2.1: hydrogenchloride / 1,4-dioxane; water; ethyl acetate / 0 - 20 °C
3.1: copper(ll) sulfate pentahydrate; triflic azide / methanol; water / 18 h
4.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C
With
hydrogenchloride; copper(ll) sulfate pentahydrate; triethylphosphite copper(I) iodide complex; triflic azide; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1021/jm201496g
