(2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene

Base Information

Chemical Name:(2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene
CAS No.:307492-79-1
Molecular Formula:C₁₄H₂₀O₅
Molecular Weight:268.31
Hs Code.:

Synonyms:(2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene

Chemical Property:

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Technology Process of (2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene

There total 11 articles about (2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 434928-87-7
(E)-2-(4-hydroxy-3-methylbut-3-en-1-yl)-4-methoxy-1-methoxymethoxybenzene

: 307492-79-1
(2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; In dichloromethane; toluene; at -24 ℃; for 24h;
DOI:10.1002/1099-0690(200009)2000:18<3223::AID-EJOC3223>3.0.CO;2-L

Reference yield: 78.0%

: 307492-78-0
C₁₄H₂₀O₄

: 307492-79-1
(2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; In dichloromethane; stereoselective reaction;
DOI:10.1016/j.bmcl.2009.12.034

Reference yield:

: 150-76-5
4-methoxy-phenol

: 307492-79-1
(2R,3R)-2-(2,3-epoxy-4-hydroxy-3-methylbutyl)-4-methoxy-1-methoxymethoxybenzene

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / PdP(Ph₃)4 / CH₂Cl₂ / 4 h / 20 °C

2: 98 percent / dimethylaminopyridine; Et₃N / ethyl acetate / 4 h / 20 °C

3: 98 percent / HCl / CH₂Cl₂ / 0.03 h / 20 °C

4: 97 percent / (i-Pr)2NEt / CH₂Cl₂ / 12 h / 40 °C

5: 97 percent / aq. K₂CO₃ / methanol / 2 h / 20 °C

6: tBuOOH; Ti(O-i-Pr)4; L-(+)-diethyl tartrate / CH₂Cl₂ / 20 h / -24 °C

With titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; dmap; diethyl (2R,3R)-tartrate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; ethyl acetate; 3: Claisen transposition / 6: Sharpless asymmetric epoxidation;
DOI:10.1039/b110578g