Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester
CAS No.:951163-61-4
Molecular Formula:C₁₁H₂₂N₂O₂
Molecular Weight:214.308
Hs Code.:2933399090
Mol file:951163-61-4.mol

Synonyms:Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester

Suppliers and Price of Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl((3S,5S)-5-Methylpiperidin-3-yl)carbamate
2.5mg
$ 160.00

Alichem
Tert-butyl((3s,5s)-5-methylpiperidin-3-yl)carbamate
1g
$ 502.95

AK Scientific
Tert-butyl((3S,5S)-5-methylpiperidin-3-yl)carbamate
500mg
$ 2144.00

Total 31 raw suppliers

Chemical Property of Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester

Chemical Property:

Boiling Point:313℃
PKA:12.38±0.40(Predicted)
Flash Point:143℃
PSA：50.36000
Density:1.00
LogP:2.22880

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl((3S,5S)-5-Methylpiperidin-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses tert-Butyl ((3S,5S)-5-Methylpiperidin-3-yl)carbamate is used in the synthetic preparation of pyrrolopyrazinylureas as JAK kinase inhibitors for the treatment of autoimmune and inflammatory diseases.

Technology Process of Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester

There total 12 articles about Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1270019-95-8,1187055-56-6,1405128-25-7
(3S,5S)-(5-Methyl-piperidin-3-yl)-carbamic acid tert-butyl ester

: 951163-61-4,1270019-95-8,1187055-56-6,1405128-25-7
(3S,5S)-(5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: (3S,5S)-(5-Methyl-piperidin-3-yl)-carbamic acid tert-butyl ester; With oxalic acid; In water; acetone; at 0 - 20 ℃; for 1.5h;

With (R)-Mandelic Acid; In acetonitrile; at 0 - 20 ℃; for 2h;

Reference yield:

: 951163-63-6
(3S,5S)-(1-benzyl-5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester

: 951163-61-4,1270019-95-8,1187055-56-6,1405128-25-7
(3S,5S)-(5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated carbon; In ethanol; at 45 ℃; under 2327.23 Torr;

Reference yield:

: 59279-60-6,130622-05-8,861658-15-3
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 951163-61-4,1270019-95-8,1187055-56-6,1405128-25-7
(3S,5S)-(5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester

Guidance literature:: dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate; With diisobutylaluminium hydride; In toluene; at -78 - -60 ℃; Inert atmosphere;

With ammonium hydroxide; acetic acid; In water; toluene; at -78 - 5 ℃;

With sodium tetrahydroborate; In water; toluene; at 5 - 20 ℃;