3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide

Base Information

• Chemical Name: 3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide
• CAS No.: 896720-65-3
• Molecular Formula: C₂₅H₂₁ClN₂O₂
• Molecular Weight: 416.907
• Mol file: 896720-65-3.mol

Synonyms:3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide

Chemical Property of 3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide

There total 1 articles about 3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-cyano-N-(4-methylphenyl)acetamide (6876-54-6) + 4-chlorochalcone (24721-26-4,956-04-7,22252-16-0) → 3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide (896720-65-3)

Guidance literature:

With morpholine; In ethanol; for 15h; Heating;

DOI:10.1016/j.bmc.2006.02.031

Reference yield: 80.0%

3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide (896720-65-3) → 2-bromo-4-(4-chlorophenyl)-N-(4-methylphenyl)-6-phenyl-3-pyridinecarboxamide (896720-66-4)

Guidance literature:

With bromine; acetic acid; at 60 - 70 ℃; for 3h;

DOI:10.1016/j.bmc.2006.02.031

Reference yield:

3-(4-chlorophenyl)-2-cyano-N-(4-methylphenyl)-5-oxo-5-phenylpentanamide (896720-65-3) → 4-(4-chloro-phenyl)-2-morpholin-4-yl-6-phenyl-N-p-tolyl-nicotinamide

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / glacial acetic acid; bromine / 3 h / 60 - 70 °C

2: 75 percent / tetrahydrofuran / 50 h / Heating

With bromine; acetic acid; In tetrahydrofuran;

DOI:10.1016/j.bmc.2006.02.031

upstream raw materials:

2-cyano-N-(4-methylphenyl)acetamide

4-chlorochalcone

Downstream raw materials:

2-bromo-4-(4-chlorophenyl)-N-(4-methylphenyl)-6-phenyl-3-pyridinecarboxamide