(2Z)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

Base Information

• Chemical Name: (2Z)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one
• CAS No.: 24721-26-4
• Molecular Formula: C15H11ClO
• Molecular Weight: 242.705
• NSC Number: 2643
• UNII: R9E58VMQ75
• DSSTox Substance ID: DTXSID401245051
• Nikkaji Number: J351.322J
• Mol file: 24721-26-4.mol

Synonyms:(Z)-4-Chlorochalcone;24721-26-4;(2Z)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one;4-Chlorochalcone, cis-;4-Chlorochalcone, (Z)-;2-Propen-1-one, 3-(4-chlorophenyl)-1-phenyl-, (2Z)-;R9E58VMQ75;Chalcone, 4-chloro-, (Z)-;(2Z)-3-(4-Chlorophenyl)-1-phenyl-2-propen-1-one;2-Propen-1-one, 3-(4-chlorophenyl)-1-phenyl-, (Z)-;NSC-2643;ST001473;UNII-R9E58VMQ75;SCHEMBL198518;NSC2643;DTXSID401245051;AKOS024273768

Chemical Property of (2Z)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 242.0498427
• Heavy Atom Count: 17
• Complexity: 271

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C=CC2=CC=C(C=C2)Cl
• Isomeric SMILES: C1=CC=C(C=C1)C(=O)/C=C\C2=CC=C(C=C2)Cl

Technology Process of (2Z)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

There total 93 articles about (2Z)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chlorobenzaldehyde (104-88-1) + acetophenone (98-86-2) → 4-chlorochalcone (24721-26-4,956-04-7,22252-16-0)

Guidance literature:

With 4 A molecular sieve; NAP-MgO; In toluene; for 17h; Heating;

DOI:10.1021/ja038954n

Reference yield: 96.0%

trans-3-(p-chlorophenyl)-1-phenyl-2,3-epoxy-1-propanone → 4-chlorochalcone (24721-26-4,956-04-7,22252-16-0)

Guidance literature:

With sodium iodide; tin(ll) chloride; In ethanol; for 0.0833333h; Reflux; Green chemistry;

DOI:10.1055/s-0034-1378821

Reference yield: 94.0%

trans-2-benzoyl-3-(4-chlorophenyl)aziridine (101854-87-9) → 4-chlorochalcone (24721-26-4,956-04-7,22252-16-0)

Guidance literature:

With dinitrogen tetraoxide; triethylamine; In tetrahydrofuran; at -23 ℃; for 0.166667h;

DOI:10.1080/00397919908086096

upstream raw materials:

4-chlorochalcone

4-chlorobenzaldehyde

α-bromoacetophenone

[[3-(4-chlorophenyl)-1-phenyl-2-propynyl]oxy]-trimethylsilane

Downstream raw materials:

4-chlorochalcone

5-Benzoyl-4-(4-chloro-phenyl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester

5-Benzoyl-4-(4-chloro-phenyl)-2-nitroso-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester

(S)-3-(4-chlorophenyl)-3-(1H-indol-3-yl)-1-phenylpropan-1-one