(E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

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Chemical Name:(E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid
CAS No.:1348742-51-7
Molecular Formula:C₁₅H₁₁F₄N₃O₄
Molecular Weight:373.264
Hs Code.:

Synonyms:(E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

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Chemical Property of (E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

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Technology Process of (E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

There total 6 articles about (E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1037590-07-0
ethyl 4-(4-fluorophenyl)-2-oxo-6-(trifluoromethyl)-2H-pyran-3-carboxylate

: 1348742-51-7
(E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

Guidance literature:: ethyl 4-(4-fluorophenyl)-2-oxo-6-(trifluoromethyl)-2H-pyran-3-carboxylate; With sodium azide; In ethanol; water; for 5h; Reflux;

With hydrogenchloride; In ethanol; water; at 20 ℃;
DOI:10.1016/j.tetlet.2011.09.149

Reference yield:

: sodium (E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylate

: 1348742-51-7
(E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

Guidance literature:: With hydrogenchloride; In water;
DOI:10.1016/j.tet.2014.09.093

Reference yield:

: 1037590-07-0
ethyl 4-(4-fluorophenyl)-2-oxo-6-(trifluoromethyl)-2H-pyran-3-carboxylate

: 1348742-51-7
(E)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

: (Z)-2-ethoxycarbonyl-3-(4-fluorophenyl)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)acrylic acid

Guidance literature:: ethyl 4-(4-fluorophenyl)-2-oxo-6-(trifluoromethyl)-2H-pyran-3-carboxylate; With sodium azide; In ethanol; for 4.5h; Reflux;

With hydrogenchloride; In ethanol; water; Overall yield = 81 %; diastereoselective reaction;
DOI:10.1016/j.tet.2014.09.093