(4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid

Base Information

Chemical Name:(4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid
CAS No.:1308917-77-2
Molecular Formula:C₂₇H₃₃N₅O₄Si
Molecular Weight:519.676
Hs Code.:

Synonyms:(4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid

Suppliers and Price of (4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid

There total 10 articles about (4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859169-20-3
1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester

: 1308917-74-9
2-amino-7-chloro-1-ethyl-3-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1H-[1,8]naphthyridin-4-one

: 1308917-77-2
(4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid

: 1308917-78-3
C₂₉H₃₇N₅O₄Si

Guidance literature:: With hydrogen carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; at 170 ℃; for 0.25h; Microwave irradiation; Sealed tube; Inert atmosphere;

Reference yield:

: 1308917-78-3
C₂₉H₃₇N₅O₄Si

: 1308917-77-2
(4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid

Guidance literature:: C₂₉H₃₇N₅O₄Si; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 70 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; pH=1;

Reference yield:

: 101226-42-0
1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carbaldehyde

: 1308917-77-2
(4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / 1,2-dimethoxyethane / -35 °C / Inert atmosphere

1.2: 0.5 h / -50 - -45 °C

1.3: 0.25 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C

3.1: hydrogen carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 0.25 h / 170 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With potassium tert-butylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol;