(S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

Base Information

Chemical Name:(S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid
CAS No.:1228440-71-8
Molecular Formula:C₃₅H₃₅F₄NO₆S₂
Molecular Weight:705.792
Hs Code.:

(S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

Synonyms:(S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

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Chemical Property of (S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

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Technology Process of (S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

There total 9 articles about (S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 324-94-7
4'-fluoro-biphenyl-4-ol

: 1228440-71-8
(S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

: 1228440-72-9
(R)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / toluene; water / 3 h / Reflux

2: ethanol; sodium tetrahydroborate / Cooling with ice

3: dmap; pyridine / 0.5 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; ethanol; tetra-(n-butyl)ammonium iodide; sodium hydroxide; In water; toluene;

Reference yield:

: 1228440-59-2
2-[(4-{2-[(4'-fluorobiphenyl-4-yl)oxy]-1-hydroxyethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 1228440-71-8
(S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

: 1228440-72-9
(R)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

Guidance literature:: With pyridine; dmap; at 20 ℃; for 0.5h;

Reference yield:

: 886527-12-4
2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazole-4-carboxylic acid

: 1228440-71-8
(S)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

: 1228440-72-9
(R)-1-{2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}-2-[(4'-fluorobiphenyl-4-yl)oxy]ethyl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: tetrahydrofuran / 1 h / Cooling with ice

2.2: Cooling with ice

2.3: pH 3 / Cooling with ice

3.1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / toluene; water / 3 h / Reflux

4.1: ethanol; sodium tetrahydroborate / Cooling with ice

5.1: dmap; pyridine / 0.5 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; ethanol; tetra-(n-butyl)ammonium iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;