1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione

Base Information

• Chemical Name: 1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione
• CAS No.: 71173-28-9
• Molecular Formula: C₁₂H₅F₆NO₂
• Molecular Weight: 309.168
• Mol file: 71173-28-9.mol

Synonyms:1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione

Chemical Property of 1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione

There total 3 articles about 1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(Z)-4-(3,5-bis(trifluoromethyl)phenylamino)-4-oxobut-2-enoic acid (72291-55-5) → 1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione (71173-28-9)

Guidance literature:

With sodium acetate; acetic anhydride; at 70 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/cmdc.201500271

Reference yield: 85.0%

maleic anhydride (108-31-6) + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → 1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione (71173-28-9)

Guidance literature:

With acetic acid; for 16h; Reflux;

DOI:10.1002/ejoc.202001593

Reference yield:

3,5-Bis-(trifluoromethyl)aniline (328-74-5) → 1-[3',5'-bis(trifluoromethyl)phenyl]-2,5-dihydropyrrole-2,5-dione (71173-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / CH₂Cl₂ / Heating

2: 30 percent / Na₂CO₃ / acetic anhydride / 1.5 h / 90 - 100 °C

With sodium carbonate; In dichloromethane; acetic anhydride;

DOI:10.1002/jhet.5570420522

upstream raw materials:

(Z)-4-(3,5-bis(trifluoromethyl)phenylamino)-4-oxobut-2-enoic acid

3,5-Bis-(trifluoromethyl)aniline

maleic anhydride

Downstream raw materials:

ethyl 10-(3,5-bis(trifluoromethyl)phenyl)-9,11-dioxo-6,9,10,11-tetrahydro-5H-pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline-8-carboxylate

C₂₆H₂₁F₆NO₃

C₂₅H₁₈ClF₆NO₃

C₂₉H₂₁F₆NO₃