6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

Base Information

Chemical Name:6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine
CAS No.:1440216-74-9
Molecular Formula:C₂₂H₂₁FN₂O₂S
Molecular Weight:396.485
Hs Code.:

Synonyms:6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

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Chemical Property of 6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

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Technology Process of 6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

There total 3 articles about 6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 170751-34-5
N,N-bis(2-butynyl)-(4-methylphenyl)sulfonamide

: 1440216-74-9
6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

Guidance literature:: With nickelocene; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; toluene; at 50 ℃; for 12h; Sealed tube;
DOI:10.1021/acs.joc.1c00577

Reference yield: 74.0%

: 459-23-4,7304-35-0
4-fluorobenzaldoxime

: 170751-34-5
N,N-bis(2-butynyl)-(4-methylphenyl)sulfonamide

: 1440216-74-9
6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In trifluoroacetic acid; at 80 ℃; for 48h; Molecular sieve;
DOI:10.1002/chem.201203909

Reference yield:

: 70-55-3
toluene-4-sulfonamide

: 1440216-74-9
6-(4-fluorophenyl)-4,7-dimethyl-2-tosyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / Reflux

2: nickelocene; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / toluene; water / 12 h / 50 °C / Sealed tube

With nickelocene; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; toluene; acetonitrile;
DOI:10.1021/acs.joc.1c00577