ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate

Base Information

Chemical Name:ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate
CAS No.:1609572-21-5
Molecular Formula:C₁₉H₁₇NO₄
Molecular Weight:323.348
Hs Code.:

Synonyms:ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate

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Chemical Property of ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate

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Technology Process of ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate

There total 4 articles about ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: ethyl 5-oxo-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate

: 70-11-1
α-bromoacetophenone

: 1609572-21-5
ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate

Guidance literature:: With potassium carbonate; In acetone; at 56 ℃; for 3h;
DOI:10.1002/ejoc.201301736

Reference yield:

: 93026-11-0
ethyl 2-[2,2-bis(ethoxycarbonyl)ethyl]nicotinate

: 1609572-21-5
ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 65 °C / Inert atmosphere

2: potassium carbonate / acetone / 3 h / 56 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetone; mineral oil; 1: |Dieckmann Condensation;
DOI:10.1002/ejoc.201301736

Reference yield:

: 1721-26-2
ethyl 2-methyl nicotinate

: 1609572-21-5
ethyl 5-oxo-6-(2-oxo-2-phenylethyl)-6,7-dihydrocyclopenta[b]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: trichloroisocyanuric acid; N,N-dimethyl-formamide / dichloromethane / 16 h / 23 °C

2: ethanol; sodium / tetrahydrofuran / 4 h / 0 - 23 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 65 °C / Inert atmosphere

4: potassium carbonate / acetone / 3 h / 56 °C

With ethanol; trichloroisocyanuric acid; sodium; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetone; mineral oil; 3: |Dieckmann Condensation;
DOI:10.1002/ejoc.201301736